Development of PLGA-based itraconazole injectable nanospheres for sustained release

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Development of PLGA-based itraconazole injectable nanospheres for sustained release

PURPOSE Itraconazole (ITZ) is a synthetic triazole antifungal agent, which is widely used for treatment and prevention of fungal infections. The purpose of this study is to develop ITZ-loaded poly(lactic-co-glycolic acid) (PLGA) nanospheres (PLGA-ITZ-NS) as a new sustained-release formulation for intravenous ITZ administration. MATERIALS AND METHODS PLGA-ITZ-NS were prepared by a nanoprecipit...

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ژورنال

عنوان ژورنال: International Journal of Nanomedicine

سال: 2013

ISSN: 1178-2013

DOI: 10.2147/ijn.s54040